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| We produce bulk quantities of all recombinant proteins. |
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Recombinant Human Leptin
| Synonyms: | Obesity protein (OB) |
| Description: | Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant human Leptin is a 16.0 kDa protein containing 147 amino acid residues. |
| Source: | E.coli |
| Stability: | The lyophilized protein is stable for at least 2 years from date of receipt at -20C. Reconstituted Leptin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20C. Avoid repeated freeze/thaw cycles. |
| Purity: | Greater than 99% by SDS-PAGE gel and HPLC analyses. |
| Biological Activity: | Globe's human Leptin is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls. |
AA Sequence: | MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC |
| 1 mg |
10 mg |
100 mg |
1 g |
| $2,000.00 |
$12,000.00 |
$60,000.00 |
$100,000.00 |
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